Searchable abstracts of presentations at key conferences in endocrinology

Endocrine Abstracts

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ea0031pl1biog | Society for Endocrinology Dale Medal Lecture | SFEBES2013

Society for Endocrinology Dale Medal Lecture

Evans Ronald M

Dr. Ronald M Evans is known for his discoveries and characterization of nuclear hormone receptors, the establishment of the nuclear receptor super family and the elucidation of their universal mechanism of action, this revealed how receptor activation by lipophilic hormones and drugs are transformed into physiology and the treatment of disease.Dr R M Evans obtained his BA and PhD from the University of California, Los Angeles, School of Medicine in 1970 ...
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ea0005s3biog | Society for Endocrinology Transatlantic Medal Lecture | BES2003

Society for Endocrinology Transatlantic Medal Lecture

Parker K

Keith Parker, University of Texas Southwestern Medical Center, Dallas, TX, USA AbstractThe son of two clinician-scientists, Keith Parker attended Williams College, and then received his M.D./Ph.D. degrees from Washington University School of Medicine in 1981. His graduate work with Donald Shreffler focused on structure-function relationships of the complement component, C4....
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ea0042oc9 | (1) | Androgens2016

Chromatin relaxation is a feature of advanced prostate cancer

Urbanucci Alfonso , Barfeld Stefan , Kytola Ville , Vodak Daniel , Sjoblom Liisa , Tolonen Teemu , Minner Sarah , Burdelski Christoph , Kivinummi Kati K. , Kregel Steven , Takhar Mandeep , Alshalalfa Mohammed , Davicioni Elai , Erho Nicholas , Karnes R. Jeffrey , Ross Ashley E. , Schaeffer Edward M. , Vander Griend Donald J. , Knapp Stefan , Tammela Teuvo L.J. , Sauter Guido , Schlomm Thorsten , Nykter Matti , Visakorpi Tapio , Mills Ian G.

Epigenetic reprogramming including altered transcription factor binding and altered patterns of chromatin and DNA modifications are now accepted as the hallmark of aggressive cancers. We show that global changes in chromatin structure and chromatin accessibility in prostate tumour tissue can define castrate-resistant prostate cancer and be used to inform the discovery of gene-level classifiers for therapy. In addition, we show that the androgen receptor overexpression alone, w...
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ea0032p681 | Neuroendocrinology | ECE2013

Hypothalamic melanin-concentrating hormone influences liver and adipose lipid metabolism

Imbernon Monica , Beiroa Daniel , Vazquez Maria J , Morgan Donald A , Veyrat-Durebex Christelle , Porteiro Begona , Diaz-Arteaga Adenis , Senra Ana , Al-Massadi Omar , Velasquez Douglas A , Gallego Rosalia , Seoane Luisa M , Lopez Miguel , Davis Roger J , Sabio Guadalupe , Rohner-Jeanrenaud Francoise , Rahmouni Kamal , Dieguez Carlos , Nogueiras Ruben

Introduction: Melanin-concentrating hormone (MCH) is an orexigenic neuropeptide which is located in the lateral hypothalamus and regulate the energy balance. MCH deficient mice are hypophagic, lean and do not develop hepatosteatosis when fed on high fat diet. The MCH increases food intake and adiposity, so we sought to investigate the role of the MCH on adipocyte and hepatic metabolism.Methods: MCH were chronically administered into the lateral ventricle...
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ea0015s56 | Transitional endocrinology | SFEBES2008

The management of Turner Syndrome from paediatric to adult care

Conway Gerard

Until recently it was usual to discharge teenagers with TS to primary care once final height had been attained in the paediatric setting. It is now clear that adults with TS benefit from dedicated TS clinics in order to optimise health care for this commonly neglected group. In adult life there is a great deal of preventable morbidity in TS which lies within the endocrine remit: osteoporosis, hypothyroidism, obesity, diabetes, hyperlipidaemia and hypertension. Other disorders ...
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ea0031pl1 | Society for Endocrinology Dale Medal Lecture | SFEBES2013

Nuclear receptors and AMPK: can exercise mimetics cure diabetes

Evans Ronald

Nuclear hormone receptors (NHRs) are a large family of ligand-activated transcription factors that regulate programs of cellular growth, differentiation and homeostasis. The structurally conserved ligand binding domains (LBDs) of NHRs bind to hydrophobic small molecules including steroid hormones, fat soluble vitamins and bile acids, thereby interpreting small molecule cues to affect transcriptional readouts.The temporal correspondence between metabolic ...
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ea0066in1.2 | (1) | BSPED2019

Dattani Mehul

Mehul Dattani is Professor of Paediatric Endocrinology based at the University College London (UCL) Great Ormond Street Institute of Child Health, and Specialty Lead in Endocrinology at Great Ormond Street Hospital for Children (GOSH). He has an active clinical practice in paediatric and adolescent Endocrinology at GOSH and University College London Hospitals (UCLH). He completed a 3-year term as Chair of the British Society for Paediatric Endocrinology and Diabetes, followed ...
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ea0042il13 | Androgen Receptor in Castration Resistant Prostate Cancer | Androgens2016

Androgen receptor: master contortionist in prostate cancer

Dehm Scott

The AR pathway accumulates myriad genomic and transcriptomic alterations during progression of prostate cancer to a lethal castration-resistant phenotype. The best characterized alterations are point mutations or amplification of the AR gene. More recently, our group had identified structural rearrangements in the AR gene as a novel class of alterations that occur frequently in castration-resistant prostate cancer (CRPC) tissues. AR gene rearrangements are associated with outl...
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ea0029ifpl1biog | The Fondation IPSEN Prize Lecture | ICEECE2012

The Fondation IPSEN Prize Winner

Paolo Sassone-Corsi

Paolo Sassone-Corsi, California, USA AbstractPaolo Sassone-Corsi is Donald Bren Professor at the University of California, Irvine, where he is Director of the Center for Epigenetics and Metabolism. He is also External Member of the Max-Planck Institute, Germany. Paolo Sassone-Corsi is an internationally recognized leader in the field of genetics and cell bi...
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ea0028pl3biog | Society for Endocrinology Transatlantic Medal Lecture | SFEBES2012

Society for Endocrinology Transatlantic Medal Lecture

Sassone-Corsi Paolo

Paolo Sassone-Corsi, University of California, Irvine, CA, USA AbstractPaolo Sassone-Corsi is Donald Bren Professor at the University of California, Irvine, where he is Director of the Center for Epigenetics and Metabolism. He is also External Member of the Max-Planck Institute, Germany. Paolo Sassone-Corsi is an internationally recognized leader in the field of genetics and cell biology. After his PhD in Italy, he ha...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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